Plastilin
Biodesign
platform
Guide natural selection with genomic technologies
PLASTILIN
We use machine learning bioinformatics algorithms and gene editing technology to creating organisms with specified characteristics.
PLASTILIN
We develop plant varieties with specified characteristics in 2 years. This approach outperforms classical breeding approaches by a factor of 10
We work with a probability of more than 90% of creating a variety with given traits, while classical selection depends on natural mutations and gives less than 5% probability
Collaboration with Plastilin costs up to 6 times less than working with crop breeding with classic approaches
Managing varieties for adaptation to climate change
We base our work on the consumer's needs by making the product with the best flavour, colour and nutritional content
Making tailored varieties for plant-based meat and alternative protein market
You don’t have to wait long for custom made crops for your needs
Key metrics of project performance
SOYBEAN
3-4
5-7
Reduced trait selection costs by ~ $1-3 million
Formed a strategy to improve the trait based on the required characteristics
Formed a strategy to improve the trait based on the required characteristics
OPTIMIZATION OF HIGH-PROTEIN SOYBEAN BREEDING STRATEGY
pea
3
6-9
Reduce trait selection costs by ~ $3-5.7 million. Obtain a region-specific variety with the necessary traits with unique positioning
Creation of a variety of peas with the necessary properties for the customer, calculated effects:
Lettuce
2-3
5-8
Up to 20% increase in growth rate Resistance to pathogens Increased vitamin and fiber content
Specialized variety of lettuce for vertical farms, potential effects:
plastilin
plastilin
years
years
plastilin
years
years
years
years
We reduce the creation of a variety by 4 times; 97% efficiency obtaining by methods of accelerated selection; 99% of getting the organism with given characteristics
deep genomics analysis
Modules of bioinformatics solution PLASTILIN for maintenance of accelerated and directed selection
Overlaying and evaluating
genotyped plant data
genotyped plant data
De novo plant genome assembly
Identification of significant
genome regions responsible
for target traits
genome regions responsible
for target traits
Overlaying and evaluating
genotyped plant data
genotyped plant data
Complete scheme
of the breeding process
using molecular biological
markers
of the breeding process
using molecular biological
markers
Curiosity about life in
all its aspects, I think,
is still the secret of
great creative people.
all its aspects, I think,
is still the secret of
great creative people.
Assessment of heterozygosity
and stability of
manifestation or
transmission of traits
and stability of
manifestation or
transmission of traits
Determination of key
areas for editing;
strategy for creating
the required genotype
using CRISPR-Cas
methods
areas for editing;
strategy for creating
the required genotype
using CRISPR-Cas
methods
Curiosity about life in all
its aspects, I think, is
still the secret of great
creative people.
its aspects, I think, is
still the secret of great
creative people.
Formation of fully
automatic generation
of the final plant genotype
automatic generation
of the final plant genotype
— Implemented modules
— Modules underway R&D
Genotyping
Genome assembly
Prediction
Genome analysis
Knowledge base
Genomic stability
Marker selection scheme
Breeding modeling
CRISPR
Deep learning property model
WE DESIGN NEW VARIANT BY MACHINE LEARNING RESULTS AND GENOME EDITING TECHNOLOGY
old version
Rapidly
perfect
plant
perfect
plant
Genomic editing allows us to produce a given genotype in one step by introducing natural mutations
We transform the foundations of biological processes
Specialized variety of pea for plant-based products, potential effects:
Yield and protein content increase
Resistance to pathogens
Increased vitamin and fiber content
Resistance to pathogens
Increased vitamin and fiber content
Specialized variety of soybean for plant-based
products, potential effects:
products, potential effects:
Increased protein content
Changing the ratio of amino acid and other organic compounds
Increased L-lysis % of aminoacidi
Changing the ratio of amino acid and other organic compounds
Increased L-lysis % of aminoacidi
pea
soybean
Tracks and achievements
Contracts with a major agricultural holding (top 5) for seed production
Two cutting-edge laboratories for variety development and scientific research
Partnerships with leading national research breeding teams
The largest collection of genomic data on legumes in Russia
Development of new CRISPR - Cas system proteins
Working with two leading producers of plant-based protein isolate
Proven hypotheses of vertical farm products with top - 1 in leaders of production systems
Tracks and achievements
Plastilin TECHNOLOGIES
2 LABORATORIES FOR IMPROVING PLANT VARIETIES
Our molecular-biological R&D is to identify key genome areas responsible for agricultural traits and to create DNA markers which enables direct selection. We are working in collaboration with The Vavilov Institute of General Genetics and with Saint Petersburg State University.
UNIQUE CRISPR-CAS PROTEINS
optimization and improving the system of CRISPR-Cas like proteins. Proven methodology of the optimal approach for editing each crop like soybeans, peas, corn, tomatoes, lettuce and mushrooms
In vitro work with plants
we perform cloning of plant culture tissue, the protocol of in-vitro culture has been worked out on soybean varieties.
Year-round cultivation and phenotyping
For the propagation and evaluation of plants, we work in greenhouse complex from a series of greenhouses and phytotron, which allows carry out year-round work with crops
New legumes variants (soybeans,
peas, chickpeas)
Launch a pilot to: develop a variety
with specified characteristics using
accelerated breeding methods
Achievement of milestones during the
acceleration period
peas, chickpeas)
Launch a pilot to: develop a variety
with specified characteristics using
accelerated breeding methods
Achievement of milestones during the
acceleration period
Speeding up the breeding programme for legumes and cereals
Launch a pilot to: optimisation of the breeding programme in one area
Analysis and development of the breeding strand
Accelerated development of the required variety from customer material using directed breeding methods (CRISPR/in vitro)
Achievement of milestones in the acceleration time
Launch a pilot to: optimisation of the breeding programme in one area
Analysis and development of the breeding strand
Accelerated development of the required variety from customer material using directed breeding methods (CRISPR/in vitro)
Achievement of milestones in the acceleration time
New generation plants for vertical farm
Launch a pilot to:develop a tomato or lettuce variety with specified characteristics using accelerated breeding methods
Achieve benchmark results during the acceleration period and launch minimum viable product
Launch a pilot to:develop a tomato or lettuce variety with specified characteristics using accelerated breeding methods
Achieve benchmark results during the acceleration period and launch minimum viable product
examples of tasks that we are ready to solve
